Visualization and quality control tools for large-scale multiplex tissue analysis in TissUUmaps3.

ABSTRACT: Large-scale multiplex tissue analysis aims to understand processes such as development and tumor formation by studying the occurrence and interaction of cells in local environments in, for example, tissue samples from patient cohorts. A typical procedure in the analysis is to delineate individual cells, classify them into cell types, and analyze their spatial relationships. All steps come with a number of challenges, and to address them and identify the bottlenecks of the analysis, it is necessary to include quality control tools in the analysis workflow. This makes it possible to optimize the steps and adjust settings in order to get better and more precise results. Additionally, the development of automated approaches for tissue analysis requires visual verification to reduce skepticism

SUBMITTER: Behanova A 

PROVIDER: S-EPMC10936381 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature