Within-species variability of antibiotic interactions in Gram-negative bacteria.

ABSTRACT: Treatments with antibiotic combinations are becoming increasingly important even though the supposed clinical benefits of combinations are, in many cases, unclear. Here, we systematically examined how several clinically used antibiotics interact and affect the antimicrobial efficacy against five especially problematic Gram-negative pathogens. A total of 232 bacterial isolates were tested against different pairwise antibiotic combinations spanning five classes, and the ability of all combinations in inhibiting growth was quantified. Descriptive statistics, principal component analysis (PCA), and Spearman's rank correlation matrix were used to determine the correlations between the different combinations on interaction outcome. Several important conclusions can be drawn from the 696 examined

SUBMITTER: Tang P-C 

PROVIDER: S-EPMC10936430 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature