The relationship between long non-coding gene CASC21 polymorphisms and cervical cancer.

ABSTRACT:

Background

CASC21 was reported to be a hotspot gene in cervical cancer. The relationship between CASC21 genetic polymorphisms and cervical cancer has not been reported. Genetic factors influence the occurrence of cervical cancer. Thus, we explored the correlation between CASC21 polymorphisms and cervical cancer.

Methods

A total of 973 participants within 494 cervical cancer cases and 479 healthy controls were recruited. Five single nucleotide polymorphisms (SNPs) in the CASC21 gene were genotyped using the Agena MassARRAY platform. Chi-squared test, logistic regression analysis, odds ratio (OR), multifactor dimensionality reduction (MDR), and 95% confidence interval (95%CI) were used for data analysis.

Results

In the overall analysis, rs169

SUBMITTER: Han L 

PROVIDER: S-EPMC10936591 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature