Ontology highlight
ABSTRACT:
SUBMITTER: Montrazi ET
PROVIDER: S-EPMC10936946 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Montrazi Elton T ET Sasson Keren K Agemy Lilach L Scherz Avigdor A Frydman Lucio L
Science advances 20240313 11
Cancer diagnosis by metabolic MRI proposes to follow the fate of glycolytic precursors such as pyruvate or glucose, and their in vivo conversion into lactate. This study compares the <sup>2</sup>H MRI outlooks afforded by these metabolites when targeting a pancreatic cancer model. Exogenously injected [3,3',3″-<sup>2</sup>H<sub>3</sub>]-pyruvate was visible only briefly; it generated a deuterated lactate signal throughout the body that faded after ~5 min, showing a minor concentration bias at th ...[more]