Time-Varying Determinants of Graft Failure in Pediatric Kidney Transplantation in Europe.

ABSTRACT:

Background

Little is known about the time-varying determinants of kidney graft failure in children.

Methods

We performed a retrospective study of primary pediatric kidney transplant recipients (younger than 18 years) from the Eurotransplant registry (1990-2020). Piece-wise exponential additive mixed models were applied to analyze time-varying recipient, donor, and transplant risk factors. Primary outcome was death-censored graft failure.

Results

We report on 4528 kidney transplantations, of which 68% with deceased and 32% with living donor. One thousand six hundred and thirty-eight recipients experienced graft failure, and 168 died with a functioning graft. Between 2011 and 2020, the 5-year graft failure risk was 10% for deceased donor and 4% for living donor kidney t

SUBMITTER: Coens F 

PROVIDER: S-EPMC10937011 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature