Efficacy of Voclosporin in Proliferative Lupus Nephritis with High Levels of Proteinuria.

ABSTRACT:

Background

In a phase 3 study of adults with active lupus nephritis, addition of voclosporin to mycophenolate mofetil (MMF) and low-dose glucocorticoids led to significant improvements in the proportion of participants achieving complete and partial renal response as well as sustained reduction in proteinuria. This analysis examined the efficacy and safety of voclosporin in a subgroup of the phase 3 study with proliferative lupus nephritis and high levels of proteinuria.

Methods

Participants were randomized to oral voclosporin (23.7 mg twice daily) or placebo for 12 months; all participants received MMF and low-dose glucocorticoids. This analysis includes participants with class III or IV (±class V) lupus nephritis and baseline urine protein-creatinine ratio (UPCR) ≥3 g/g. E

SUBMITTER: Menn-Josephy H 

PROVIDER: S-EPMC10937024 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature