Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression.

ABSTRACT: Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major challenge. Here, we combine RNA sequencing with selective pharmacological, chemogenetic, and optogenetic manipulations to isolate the contribution of the locus coeruleus-noradrenaline (LC-NA) system to the acute stress response in mice. We reveal that NA release during stress exposure regulates a large and reproducible set of genes in the dorsal and ventral hippocampus via β-adrenergic receptors. For a smaller subset of these genes, we show that NA release triggered by LC stimulation is sufficient to mimic the stress-induced transcriptional response. We observe these effects in both sexes, and indepen

SUBMITTER: Privitera M 

PROVIDER: S-EPMC10937036 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature