The role of endothelial shear stress, shear stress gradient, and plaque topography in plaque erosion.

ABSTRACT:

Background and aims

Plaque erosion is a common underlying cause of acute coronary syndromes. The role of endothelial shear stress (ESS) and endothelial shear stress gradient (ESSG) in plaque erosion remains unknown. We aimed to determine the role of ESS metrics and maximum plaque slope steepness in plaques with erosion versus stable plaques.

Methods

This analysis included 46 patients/plaques from TOTAL and COMPLETE trials and Brigham and Women's Hospital's database who underwent angiography and OCT. Plaques were divided into those with erosion (n = 24) and matched stable coronary plaques (n = 22). Angiographic views were used to generate a 3-D arterial reconstruction, with centerlines merged from angiography and OCT pullback. Local ESS metrics were assessed by computational

SUBMITTER: Hakim D 

PROVIDER: S-EPMC10937042 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature