Spatial transcriptomics reveal neuron-astrocyte synergy in long-term memory.

ABSTRACT: Memory encodes past experiences, thereby enabling future plans. The basolateral amygdala is a centre of salience networks that underlie emotional experiences and thus has a key role in long-term fear memory formation¹. Here we used spatial and single-cell transcriptomics to illuminate the cellular and molecular architecture of the role of the basolateral amygdala in long-term memory. We identified transcriptional signatures in subpopulations of neurons and astrocytes that were memory-specific and persisted for weeks. These transcriptional signatures implicate neuropeptide and BDNF signalling, MAPK and CREB activation, ubiquitination pathways, and synaptic connectivity as key components of long-term memory. Notably, upon long-term memory formation, a neuronal subpopulation define

SUBMITTER: Sun W 

PROVIDER: S-EPMC10937396 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature