Large-scale gene expression alterations introduced by structural variation drive morphotype diversification in Brassica oleracea.

ABSTRACT: Brassica oleracea, globally cultivated for its vegetable crops, consists of very diverse morphotypes, characterized by specialized enlarged organs as harvested products. This makes B. oleracea an ideal model for studying rapid evolution and domestication. We constructed a B. oleracea pan-genome from 27 high-quality genomes representing all morphotypes and their wild relatives. We identified structural variations (SVs) among these genomes and characterized these in 704 B. oleracea accessions using graph-based genome tools. We show that SVs exert bidirectional effects on the expression of numerous genes, either suppressing through DNA methylation or promoting probably by harboring transcription factor-binding elements. The following examples illustrate the role of SVs modulating gene express

SUBMITTER: Li X 

PROVIDER: S-EPMC10937405 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature