Effect of leukoreduction on the metabolism of equine packed red blood cells during refrigerated storage.

ABSTRACT:

Background

Understanding of the biochemical and morphological lesions associated with storage of equine blood is limited.

Objective

To demonstrate the temporal sequences of lipid and metabolic profiles of equine fresh and stored (up to 42 days) and leukoreduced packed red blood cells (LR-pRBC) and non-leukoreduced packed RBC (nLR-pRBC).

Animals

Packed RBC units were obtained from 6 healthy blood donor horses enrolled in 2 blood banks.

Methods

Observational study. Whole blood was collected from each donor using transfusion bags with a LR filter. Leukoreduction pRBC and nLR-pRBC units were obtained and stored at 4°C for up 42 days. Sterile weekly sampling was performed from each unit for analyses.

Results

Red blood cells and supernatants progressively accu

SUBMITTER: Miglio A 

PROVIDER: S-EPMC10937500 | biostudies-literature | 2024 Mar-Apr

REPOSITORIES: biostudies-literature