Survivin in lung cancer: a potential target for therapy and prevention-a narrative review.

ABSTRACT:

Background and objective

A versatile biomarker, survivin, is highly expressed in proliferating cells of multiple cancers in humans and animals. It is an apoptosis-regulating protein, engaging in a cascade of reactions that involve several other genes and protein interactions. Currently, researchers are investigating its therapeutic potential due to the evidence linking its overexpression to advanced-stage lung cancer. This review is centered around examining survivin-related molecular mechanisms and its therapeutic role specifically in lung cancer. Our objective is to discuss the role of survivin in prognosis and treatment response, shedding light on immune-targeted therapies, as well as outlining future directions for survivin-based vaccines in lung cancer.

Methods

The PubM

SUBMITTER: Pachimatla AG 

PROVIDER: S-EPMC10938099 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature