Cardiovascular Significance and Genetics of Epicardial and Pericardial Adiposity.

ABSTRACT:

Importance

Epicardial and pericardial adipose tissue (EPAT) has been associated with cardiovascular diseases such as atrial fibrillation or flutter (AF) and coronary artery disease (CAD), but studies have been limited in sample size or drawn from selected populations. It has been suggested that the association between EPAT and cardiovascular disease could be mediated by local or paracrine effects.

Objective

To evaluate the association of EPAT with prevalent and incident cardiovascular disease and to elucidate the genetic basis of EPAT in a large population cohort.

Design, setting, and participants

A deep learning model was trained to quantify EPAT area from 4-chamber magnetic resonance images using semantic segmentation. Cross-sectional and prospective cardiovascular

SUBMITTER: Ramo JT 

PROVIDER: S-EPMC10938251 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature