TP63-TRIM29 axis regulates enhancer methylation and chromosomal instability in prostate cancer.

ABSTRACT:

Background

Prostate adenocarcinoma (PRAD) is the second leading cause of cancer-related deaths in men. High variability in DNA methylation and a high rate of large genomic rearrangements are often observed in PRAD.

Results

To investigate the reasons for such high variance, we integrated DNA methylation, RNA-seq, and copy number alterations datasets from The Cancer Genome Atlas (TCGA), focusing on PRAD, and employed weighted gene co-expression network analysis (WGCNA). Our results show that only single cluster of co-expressed genes is associated with genomic and epigenomic instability. Within this cluster, TP63 and TRIM29 are key transcription regulators and are downregulated in PRAD. We discovered that TP63 regulates the level of enhancer methylation in prostate basal epithe

SUBMITTER: Sultanov R 

PROVIDER: S-EPMC10938740 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature