Modulation of Dendritic Cell Function via Nanoparticle-Induced Cytosolic Calcium Changes.

ABSTRACT: Calcium nanoparticles have been investigated for applications, such as drug and gene delivery. Additionally, Ca²⁺ serves as a crucial second messenger in the activation of immune cells. However, few studies have systematically studied the effects of calcium nanoparticles on the calcium levels and functions within immune cells. In this study, we explore the potential of calcium nanoparticles as a vehicle to deliver calcium into the cytosol of dendritic cells (DCs) and influence their functions. We synthesized calcium hydroxide nanoparticles, coated them with a layer of silica to prevent rapid degradation, and further conjugated them with anti-CD205 antibodies to achieve targeted delivery to DCs. Our results indicate that these nanoparticles can efficiently enter DCs and release c

SUBMITTER: Cao Z 

PROVIDER: S-EPMC10938921 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature