Unravelling the link between SARS-CoV-2 mutation frequencies, patient comorbidities, and structural dynamics.

ABSTRACT: Genomic surveillance is crucial for tracking emergence and spread of novel variants of pathogens, such as SARS-CoV-2, to inform public health interventions and to enforce control measures. However, in some settings especially in low- and middle- income counties, where sequencing platforms are limited, only certain patients get to be selected for sequencing surveillance. Here, we show that patients with multiple comorbidities potentially harbour SARS-CoV-2 with higher mutation rates and thus deserve more attention for genomic surveillance. The relationship between the patient comorbidities, and type of amino acid mutations was assessed. Correlation analysis showed that there was a significant tendency for mutations to occur within the ORF1a region for patients with higher number of comorbid

SUBMITTER: Azzeri A 

PROVIDER: S-EPMC10939192 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature