A pragmatic reevaluation of the efficacy of nonhuman primate optogenetics for psychiatry.

ABSTRACT: Translational neuroscience is committed to generating discoveries in the laboratory that ultimately can improve human lives. Optogenetics has received considerable attention because of its demonstrated promise in rodent brains to manipulate cells and circuits. In a recent report, Tremblay et al. [28] introduce an open resource detailing optogenetic studies of the nonhuman primate (NHP) brain and make robust claims about the translatability of the technology. We propose that their quantitative (e.g. a 91% success rate) and theoretical claims are questionable because the data were analyzed at a level relevant to the rodent but not NHP brain. Injections were clustered within a few monkeys in a few studies in a few brain regions, and their definitions of success were not clearly relevan

SUBMITTER: Bliss-Moreau E 

PROVIDER: S-EPMC10939311 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature