Ontology highlight
ABSTRACT:
SUBMITTER: Su AJ
PROVIDER: S-EPMC10939502 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Su Amanda J AJ Yendluri Siri C SC Ünal Elçin E
eLife 20240227
The mitosis to meiosis transition requires dynamic changes in gene expression, but whether and how the mitotic transcriptional machinery is regulated during this transition is unknown. In budding yeast, SBF and MBF transcription factors initiate the mitotic gene expression program. Here, we report two mechanisms that work together to restrict SBF activity during meiotic entry: repression of the SBF-specific Swi4 subunit through LUTI-based regulation and inhibition of SBF by Whi5, a functional ho ...[more]