Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice.

ABSTRACT: Fentanyl exposure and overdose are growing concerns in public health and occupational safety. This study aimed to establish parameters of fentanyl lethality in SKH1 mice for future overdose research. Lethality was determined using the up-down procedure, with subjects monitored post-administration using pulse oximetry (5 min) and then whole-body plethysmography (40 min). Following the determination of subcutaneous dose-response, [18F]Fluorodeoxyglucose positron emission tomography (¹⁸ F-FDG PET) was performed after LD10 fentanyl at 40 min, 6 h, 24 h or 7 days post-dose. LD10 and LD50 were observed to be 110 and 135 mg/kg, respectively, and consistent with four-parameter logistic fit values of 111.2 and 134.6 mg/kg (r²  = 0.9996). Overdose (LD10 or greater) yielded thre

SUBMITTER: Newman M 

PROVIDER: S-EPMC10939806 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature