Reorganization of mitochondria-organelle interactions during postnatal development in skeletal muscle.

ABSTRACT: Skeletal muscle cellular development requires the integrated assembly of mitochondria and other organelles adjacent to the sarcomere in support of muscle contractile performance. However, it remains unclear how interactions among organelles and with the sarcomere relates to the development of muscle cell function. Here, we combine 3D volume electron microscopy, proteomic analyses, and live cell functional imaging to investigate the postnatal reorganization of mitochondria-organelle interactions in skeletal muscle. We show that while mitochondrial networks are disorganized and loosely associated with the contractile apparatus at birth, contact sites among mitochondria, lipid droplets and the sarcoplasmic reticulum are highly abundant in neonatal muscles. The maturation process is characteri

SUBMITTER: Kim Y 

PROVIDER: S-EPMC10939894 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature