Responses to a "Typical" Morning Dose of Kratom in People Who Use Kratom Regularly: A Direct-Observation Study.

ABSTRACT:

Introduction

Use of kratom has outpaced systematic study of its effects, with most studies reliant on retrospective self-report.

Methods

We aimed to assess acute effects following kratom use in adults who use regularly, and quantify alkaloids in the products, urine, and plasma. Between July and November 2022, 10 adults came to our clinic and orally self-administered their typical kratom dose; blinding procedures were not used. Physiological measures included blood pressure, respiratory rate, heart rate, pulse oximetry, temperature, and pupil diameter. Subjective outcomes included Subjective Opioid Withdrawal Scale, Addiction Research Center Inventory, and Drug Effects Questionnaire. Psychomotor performance was also assessed.

Results

Participants were 6 men and 4 women

SUBMITTER: Smith KE 

PROVIDER: S-EPMC10939942 | biostudies-literature | 2024 Mar-Apr 01

REPOSITORIES: biostudies-literature