Data-driven MRI analysis reveals fitness-related functional change in default mode network and cognition following an exercise intervention.

ABSTRACT: Previous research has indicated that cardiorespiratory fitness (CRF) is structurally and functionally neuroprotective in older adults. However, questions remain regarding the mechanistic role of CRF on cognitive and brain health. The purposes of this study were to investigate if higher pre-intervention CRF was associated with greater change in functional brain connectivity during an exercise intervention and to determine if the magnitude of change in connectivity was related to better post-intervention cognitive performance. The sample included low-active older adults (n = 139) who completed a 6-month exercise intervention and underwent neuropsychological testing, functional neuroimaging, and CRF testing before and after the intervention. A data-driven multi-voxel pattern analysis was perf

SUBMITTER: Lloyd KM 

PROVIDER: S-EPMC10939950 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature