Association of Early Dexmedetomidine Utilization With Clinical and Functional Outcomes Following Moderate-Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study.

ABSTRACT:

Objective

To examine early sedation patterns, as well as the association of dexmedetomidine exposure, with clinical and functional outcomes among mechanically ventilated patients with moderate-severe traumatic brain injury (msTBI).

Design

Retrospective cohort study with prospectively collected data.

Setting

Eighteen Level-1 Trauma Centers, United States.

Patients

Adult (age > 17) patients with msTBI (as defined by Glasgow Coma Scale < 13) who required mechanical ventilation from the Transforming Clinical Research and Knowledge in TBI (TRACK-TBI) study.

Interventions

None.

Measurements and main results

Using propensity-weighted models, we examined the association of early dexmedetomidine exposure (within the first 5 d of ICU admission) with the pri

SUBMITTER: Liu SY 

PROVIDER: S-EPMC10939970 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature