A synthesis and subgroup analysis of the eosinophilic esophagitis tissue transcriptome.

ABSTRACT:

Background

Eosinophilic esophagitis (EoE) is a chronic immune mediated inflammatory disorder of the esophagus. It is still unknown why children and adults present differently, and there is little evidence about why it is more common in men than women.

Objective

Our aim was to synthesize published and unpublished esophageal bulk RNA-sequencing (RNA-seq) data to gain novel insights into the pathobiology of EoE and examine the differences in EoE transcriptome by sex and age group.

Methods

Esophageal bulk RNA-seq data from 5 published and 2 unpublished studies resulting in 137 subjects (EoE: N = 76; controls: N = 61) were analyzed. For overall analysis, combined RNA-seq data of patients with EoE were compared with those of controls and subgroup analysis was conducted in p

SUBMITTER: Jacobse J 

PROVIDER: S-EPMC10939980 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature