Desirability of outcome ranking for obstetrical trials: illustration and application to the ARRIVE trial.

ABSTRACT:

Background

In randomized trials, 1 primary outcome is typically chosen to evaluate the consequences of an intervention, whereas other important outcomes are relegated to secondary outcomes. This issue is amplified for many obstetrical trials in which an intervention may have consequences for both the pregnant person and the child. In contrast, desirability of outcome ranking, a paradigm shift for the design and analysis of clinical trials based on patient-centric evaluation, allows multiple outcomes-including from >1 individual-to be considered concurrently.

Objective

This study aimed to describe desirability of outcome ranking methodology tailored to obstetrical trials and to apply the methodology to maternal-perinatal paired (dyadic) outcomes in which both individuals may

SUBMITTER: Sandoval GJ 

PROVIDER: S-EPMC10939984 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature