Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts.

ABSTRACT: The impact of tobacco exposure on health varies by race and ethnicity and is closely tied to internal nicotine dose, a marker of carcinogen uptake. DNA methylation is strongly responsive to smoking status and may mediate health effects, but study of associations with internal dose is limited. We performed a blood leukocyte epigenome-wide association study (EWAS) of urinary total nicotine equivalents (TNEs; a measure of nicotine uptake) and DNA methylation measured using the MethylationEPIC v1.0 BeadChip (EPIC) in six racial and ethnic groups across three cohort studies. In the Multiethnic Cohort Study (discovery, n = 1994), TNEs were associated with differential methylation at 408 CpG sites across >250 genomic regions (p < 9 × 10^-8). The top significant sites were annotated to A

SUBMITTER: Huang BZ 

PROVIDER: S-EPMC10940014 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature