The association of GNB5 with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function.

ABSTRACT: Disease-associated variants identified from genome-wide association studies (GWASs) frequently map to non-coding areas of the genome such as introns and intergenic regions. An exclusive reliance on gene-agnostic methods of genomic investigation could limit the identification of relevant genes associated with polygenic diseases such as Alzheimer disease (AD). To overcome such potential restriction, we developed a gene-constrained analytical method that considers only moderate- and high-risk variants that affect gene coding sequences. We report here the application of this approach to publicly available datasets containing 181,388 individuals without and with AD and the resulting identification of 660 genes potentially linked to the higher AD prevalence among Africans/African Americans. By i

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10940018 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature