A Genomic Urine Assay for Surveillance of Patients with Bladder Cancer Treated with Radiotherapy.

ABSTRACT:

Background

Patients with muscle-invasive bladder cancer (MIBC) who receive radiotherapy with curative intent are followed by imaging, cystoscopy, and urine cytology. However, interpretation of cytology and cystoscopy is hampered by the impact of ionizing radiation on cells.

Objective

To assess the diagnostic performance of a genomic urine assay to detect urinary tract recurrences in patients with MIBC treated by (chemo)radiation.

Design setting and participants

Patients with nonmetastatic MIBC who underwent (chemo)radiation with curative intent from 2016 to 2020 were prospectively included. Follow-up consisted of cystoscopy and upper tract imaging. Prior to cystoscopy, a urine sample was analyzed to assess mutations in the genes FGFR3, HRAS, and TERT<

SUBMITTER: de Jong FC 

PROVIDER: S-EPMC10940129 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature