Siglec-15 on macrophages suppress the immune microenvironment in patients with PD-L1 negative non-metastasis lung adenocarcinoma.

ABSTRACT: Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is an immune checkpoint molecule with sequence homology to programmed cell death ligand 1 (PD-L1), which is mainly expressed on macrophages and tumor cells. However, whether Siglec-15-induced immunosuppression and poor prognosis are independent of PD-L1 remains unclear. In this study, we collected samples of 135 non-small cell lung cancers and found that Siglec-15 and PD-L1 expression were independent in non-small cell lung cancer by multiple immunofluorescence staining. Siglec-15 on macrophages (Mφ-Siglec-15) was significantly associated with DFS (p < 0.05) in PD-L1^- patients with non-metastasis lung adenocarcinoma, not in PD-L1⁺ or lung squamous cell carcinoma patients. Moreover, stromal Siglec-15^+</

SUBMITTER: Huang Z 

PROVIDER: S-EPMC10940158 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature