Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies.

ABSTRACT:

Background

A healthy lifestyle is associated with a lower premature mortality risk and with longer life expectancy. However, the metabolic pathways of a healthy lifestyle and how they relate to mortality and longevity are unclear. We aimed to identify and replicate a healthy lifestyle metabolomic signature and examine how it is related to total and cause-specific mortality risk and longevity.

Methods

In four large cohorts with 13,056 individuals and 28-year follow-up, we assessed five healthy lifestyle factors, used liquid chromatography mass spectrometry to profile plasma metabolites, and ascertained deaths with death certificates. The unique healthy lifestyle metabolomic signature was identified using an elastic regression. Multivariable Cox regressions were used to assess

SUBMITTER: Tessier AJ 

PROVIDER: S-EPMC10940196 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature