Targeted Proteomics Reveals Functional Targets for Early Diabetes Susceptibility in Young Adults.

ABSTRACT:

Background

The circulating proteome may encode early pathways of diabetes susceptibility in young adults for surveillance and intervention. Here, we define proteomic correlates of tissue phenotypes and diabetes in young adults.

Methods

We used penalized models and principal components analysis to generate parsimonious proteomic signatures of diabetes susceptibility based on phenotypes and on diabetes diagnosis across 184 proteins in >2000 young adults in the CARDIA (Coronary Artery Risk Development in Young Adults study; mean age, 32 years; 44% women; 43% Black; mean body mass index, 25.6±4.9 kg/m²), with validation against diabetes in >1800 individuals in the FHS (Framingham Heart Study) and WHI (Women's Health Initiative).

Results

In 184 proteins in >2000

SUBMITTER: Shah RV 

PROVIDER: S-EPMC10940209 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature