Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic biomarker and gene therapy target.

ABSTRACT:

Purpose

Pancreatic cancer (PC) is a highly malignant tumor that poses a severe threat to human health. Brain glycogen phosphorylase (PYGB) breaks down glycogen and provides an energy source for tumor cells. Although PYGB has been reported in several tumors, its role in PC remains unclear.

Methods

We constructed a risk diagnostic model of PC-related genes by WGCNA and LASSO regression and found PYGB, an essential gene in PC. Then, we explored the pro-carcinogenic role of PYGB in PC by in vivo and in vitro experiments.

Results

We found that PYGB, SCL2A1, and SLC16A3 had a significant effect on the diagnosis and prognosis of PC, but PYGB had the most significant effect on the prognosis. Pan-cancer analysis showed that PYGB was highly expressed in most of the tumors but h

SUBMITTER: Ren LK 

PROVIDER: S-EPMC10940407 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature