Prediction of virus-host interactions and identification of hot spot residues of DENV-2 and SH3 domain interactions.

ABSTRACT: Dengue virus, particularly serotype 2 (DENV-2), poses a significant global health threat, and understanding the molecular basis of its interactions with host cell proteins is imperative for developing targeted therapeutic strategies. This study elucidated the interactions between proline-enriched motifs and Src homology 3 (SH3) domain. The SH3 domain is pivotal in mediating protein-protein interactions, particularly by recognizing and binding to proline-rich regions in partner proteins. Through a computational pipeline, we analyzed the interactions and binding modes of proline-enriched motifs with SH3 domains, identified new potential DENV-2 interactions with the SH3 domain, and revealed potential hot spot residues, underscoring their significance in the viral life cycle. This comprehensiv

SUBMITTER: Banik M 

PROVIDER: S-EPMC10940428 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature