Txnip regulates the Oct4-mediated pluripotency circuitry via metabolic changes upon differentiation.

ABSTRACT: Thioredoxin interacting protein (Txnip) is a stress-responsive factor regulating Trx1 for redox balance and involved in diverse cellular processes including proliferation, differentiation, apoptosis, inflammation, and metabolism. However, the biological role of Txnip function in stem cell pluripotency has yet to be investigated. Here, we reveal the novel functions of mouse Txnip in cellular reprogramming and differentiation onset by involving in glucose-mediated histone acetylation and the regulation of Oct4, which is a fundamental component of the molecular circuitry underlying pluripotency. During reprogramming or PSC differentiation process, cellular metabolic and chromatin remodeling occur in order to change its cellular fate. Txnip knockout promotes induced pluripotency but hinders in

SUBMITTER: Kwak S 

PROVIDER: S-EPMC10940461 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature