Glioblastoma in the oldest old: Clinical characteristics, therapy, and outcome in patients aged 80 years and older.

ABSTRACT:

Background

Incidence rates of glioblastoma in very old patients are rising. The standard of care for this cohort is only partially defined and survival remains poor. The aims of this study were to reveal current practice of tumor-specific therapy and supportive care, and to identify predictors for survival in this cohort.

Methods

Patients aged 80 years or older at the time of glioblastoma diagnosis were retrospectively identified in 6 clinical centers in Switzerland and France. Demographics, clinical parameters, and survival outcomes were annotated from patient charts. Cox proportional hazards modeling was performed to identify parameters associated with survival.

Results

Of 107 patients, 45 were diagnosed by biopsy, 30 underwent subtotal resection, and 25 had gross t

SUBMITTER: Stadler C 

PROVIDER: S-EPMC10940826 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature