Association of methylation risk score with incident type 2 diabetes mellitus: A nested case-control study.

ABSTRACT:

Aims

To investigate the association of methylation risk score (MRS) and its interactions with environmental factors with type 2 diabetes mellitus (T2DM) risk.

Methods

We conducted a nested case-control study with 241 onset cases and 241 matched controls. Conditional logistic regression models were employed to identify risk CpG sites. Simple and weighted MRSs were constructed based on the methylation levels of ATP-binding cassette G1 gene, fat mass and obesity associated gene, potassium voltage-gated channel member 1 gene, and thioredoxin-interacting protein gene previously associated with T2DM to estimate the association of MRS with T2DM risk. Stratified analyses were used to investigate interactions between MRS and environmental factors.

Results

A total of 10 CpG loc

SUBMITTER: Huo W 

PROVIDER: S-EPMC10940902 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature