Polygenic Risk Scores for Glaucoma Onset in the Ocular Hypertension Treatment Study.

ABSTRACT:

Importance

Primary open-angle glaucoma (POAG) is a highly heritable disease, with 127 identified risk loci to date. Polygenic risk score (PRS) may provide a clinically useful measure of aggregate genetic burden and improve patient risk stratification.

Objective

To assess whether a PRS improves prediction of POAG onset in patients with ocular hypertension.

Design, setting, and participants

This was a post hoc analysis of the Ocular Hypertension Treatment Study. Data were collected from 22 US sites with a mean (SD) follow-up of 14.0 (6.9) years. A total of 1636 participants were followed up from February 1994 to December 2008; 1077 participants were enrolled in an ancillary genetics study, of which 1009 met criteria for this analysis. PRS was calculated using summary st

SUBMITTER: Singh RK 

PROVIDER: S-EPMC10941023 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature