The effects of Massa Medicata Fermentata on the digestive function and intestinal flora of mice with functional dyspepsia.

ABSTRACT: Introduction: The purpose of this study was to identify the chemical components of Massa Medicata Fermentata (MMF) in different fermentation methods, analyze its regulatory effects on gastrointestinal propulsion and intestinal flora in mice with food accumulation, and further explore its mechanism of action in the treatment of dyspepsia. Methods: The chemical compositions of three kinds of MMF were identified using the UPLC-Q- Exactive Orbitrap mass spectrometer. A model of spleen deficiency and food accumulation in mice was established. The gastric emptying rate and intestinal propulsion rate were calculated, serum gastrin concentration and cholinesterase activity were measured, and 16S rRNA microbial detection was performed in different groups of mouse feces. Results:

SUBMITTER: Wang S 

PROVIDER: S-EPMC10941201 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature