Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology.

ABSTRACT: The host immune system status remains an unresolved mystery among several malignancies. An immune-compromised state or smart immune-surveillance tactics orchestrated by cancer cells are the primary cause of cancer invasion and metastasis. Taking a closer look at the tumour-immune microenvironment, a complex network and crosstalk between infiltrating immune cells and cancer cells mediated by cytokines, chemokines, exosomal mediators and shed ligands are present. Cytokines such as interleukins can influence all components of the tumour microenvironment (TME), consequently promoting or suppressing tumour invasion based on their secreting source. Interleukin-10 (IL-10) is an interlocked cytokine that has been associated with several types of malignancies and proved to have paradoxical effects.

SUBMITTER: Elemam NM 

PROVIDER: S-EPMC10941350 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature