Causal association between helicobacter pylori and atherosclerosis: a two-sample Mendelian randomization.

ABSTRACT:

Background

Helicobacter pylori (H. pylori), according to a number of recent observational studies, is connected to atherosclerosis (AS). However, the link between H. pylori and AS is debatable.

Methods

In order to calculate the causal relationship between H. pylori and AS, we employed a two-sample Mendelian randomization (MR) analysis. The data for H. pylori were obtained from the IEU GWAS database ( https://gwas.mrcieu.ac.uk/datasets/ ) and the data for AS were obtained from the Finngen GWAS database ( https://r5.finngen.fi/ ). We selected single nucleotide polymorphisms with a threshold of 5 × 10^-6 from earlier genome-wide association studies. MR was performed mainly using the inverse variance weighted (IVW) method. To ensure the reliability of the findings, We

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10941435 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature