Transplanted human photoreceptors transfer cytoplasmic material but not to the recipient mouse retina.

ABSTRACT:

Background

The discovery of material transfer between transplanted and host mouse photoreceptors has expanded the possibilities for utilizing transplanted photoreceptors as potential vehicles for delivering therapeutic cargo. However, previous research has not directly explored the capacity for human photoreceptors to engage in material transfer, as human photoreceptor transplantation has primarily been investigated in rodent models of late-stage retinal disease, which lack host photoreceptors.

Methods

In this study, we transplanted human stem-cell derived photoreceptors purified from human retinal organoids at different ontological ages (weeks 10, 14, or 20) into mouse models with intact photoreceptors and assessed transfer of human proteins and organelles to mouse photorec

SUBMITTER: Ho MT 

PROVIDER: S-EPMC10941468 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature