The potential role of Listeria monocytogenes in promoting colorectal adenocarcinoma tumorigenic process.

ABSTRACT:

Background

Listeria monocytogenes is a foodborne pathogen, which can cause a severe illness, especially in people with a weakened immune system or comorbidities. The interactions between host and pathogens and between pathogens and tumor cells have been debated in recent years. However, it is still unclear how bacteria can interact with tumor cells, and if this interaction can affect tumor progression and therapy.

Methods

In this study, we evaluated the involvement of L. monocytogenes in pre-neoplastic and colorectal cancer cell proliferation and tumorigenic potential.

Results

Our findings showed that the interaction between heat-killed L. monocytogenes and pre-neoplastic or colorectal cancer cells led to a proliferative induction; furthermore, by using a three-dimens

SUBMITTER: Baldelli G 

PROVIDER: S-EPMC10941472 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature