Sex disparities revealed by single-cell and bulk sequencing and their impacts on the efficacy of immunotherapy in esophageal cancer.

ABSTRACT:

Background

There is an ongoing debate on whether sex affects immune-suppressive tumor microenvironment and immunotherapy. Here, we explored the underlying molecular bases for sex dimorphisms and their impact on the efficacy of immunotherapy in esophageal cancer (EC).

Methods

2360 EC patients from phase 3 trials were pooled to compare overall survivals by calculating hazard ratios (HRs) and their 95% confidence intervals (CIs). Genomic data of 1425 samples were integrated to depict the genomic landscapes and antigenic features. We also examined the sex disparities based on single-cell RNA sequencing and T cell receptor-sequencing data from 105,145 immune cells in 60 patients.

Results

Immunotherapy was associated with favorable outcomes in men (HR, 0.71; 95% CI, 0.65-0.

SUBMITTER: Yan H 

PROVIDER: S-EPMC10941500 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature