Glial cells are affected more than interneurons by the loss of Engrailed 2 gene in the mouse cerebellum.

ABSTRACT: Glial cells play a pivotal role in the inflammatory processes, which are common features of several neurodevelopmental and neurodegenerative disorders. Their major role in modulating neuroinflammation underscores their significance in these conditions. Engrailed-2 knockout mice (En2^-/- ) are considered a valuable model for autism spectrum disorder (ASD) due to their distinctive neuroanatomical and behavioral traits. Given the higher prevalence of ASD in males, our objective was to investigate glial and interneuron alterations in the cerebellum of En2^-/- mice compared with wild-type (WT) mice in both sexes. We employed immunohistochemical analysis to assess cell density for all cell types studied and analyzed the area (A) and shape factor (SF) of microglia cell bodies.

SUBMITTER: Lazzarini G 

PROVIDER: S-EPMC10941518 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature