Radiation-induced effects on TGF-β and PDGF receptor signaling in cancer-associated fibroblasts.

ABSTRACT:

Background

Cancer-associated fibroblasts (CAFs) consist of heterogeneous connective tissue cells and are often constituting the most abundant cell type in the tumor stroma. Radiation effects on tumor stromal components like CAFs in the context of radiation treatment is not well-described.

Aim

This study explores potential changes induced by ionizing radiation (IR) on platelet-derived growth factor (PDGF)/PDGFRs and transforming growth factor-beta (TGF-β)/TGFβRs signaling systems in CAFs.

Methods and results

Experiments were carried out by employing primary cultures of human CAFs isolated from freshly resected non-small cell lung carcinoma tumor tissues. CAF cultures from nine donors were treated with one high (1 × 18 Gy) or three fractionated (3 × 6 Gy) radiation dose

SUBMITTER: Yang N 

PROVIDER: S-EPMC10941573 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature