Virtual twins for model-informed precision dosing of clozapine in patients with treatment-resistant schizophrenia.

ABSTRACT: Model-informed precision dosing using virtual twins (MIPD-VTs) is an emerging strategy to predict target drug concentrations in clinical practice. Using a high virtualization MIPD-VT approach (Simcyp version 21), we predicted the steady-state clozapine concentration and clozapine dosage range to achieve a target concentration of 350 to 600 ng/mL in hospitalized patients with treatment-resistant schizophrenia (N = 11). We confirmed that high virtualization MIPD-VT can reasonably predict clozapine concentrations in individual patients with a coefficient of determination (R² ) ranging between 0.29 and 0.60. Importantly, our approach predicted the final dosage range to achieve the desired target clozapine concentrations in 73% of patients. In two thirds of patients treated with fluv

SUBMITTER: Mostafa S 

PROVIDER: S-EPMC10941576 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature