Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoter.

ABSTRACT:

Background

Ovarian cancer (OC) is distinguished by its aggressive nature and the limited efficacy of current treatment strategies. Recent studies have emphasized the significant role of cancer-associated fibroblasts (CAFs) in OC development and progression.

Methods

Employing sophisticated machine learning techniques on bulk transcriptomic datasets, we identified fibroblast growth factor 7 (FGF7), derived from CAFs, as a potential oncogenic factor. We investigated the relationship between FGF7 expression and various clinical parameters. A series of in vitro experiments were undertaken to evaluate the effect of CAFs-derived FGF7 on OC cell activities, such as proliferation, migration, and invasion. Single-cell transcriptomic analysis was also conducted to elucidate the interac

SUBMITTER: Feng S 

PROVIDER: S-EPMC10941588 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature