Key considerations to improve the normalization, interpretation and reproducibility of morbidity data in mammalian models of viral disease.

ABSTRACT: Viral pathogenesis and therapeutic screening studies that utilize small mammalian models rely on the accurate quantification and interpretation of morbidity measurements, such as weight and body temperature, which can vary depending on the model, agent and/or experimental design used. As a result, morbidity-related data are frequently normalized within and across screening studies to aid with their interpretation. However, such data normalization can be performed in a variety of ways, leading to differences in conclusions drawn and making comparisons between studies challenging. Here, we discuss variability in the normalization, interpretation, and presentation of morbidity measurements for four model species frequently used to study a diverse range of human viral pathogens - mice, hamster

SUBMITTER: Belser JA 

PROVIDER: S-EPMC10941659 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature