Biological differences of three paclitaxel- and sirolimus-coated balloons on coronary lesions in a rabbit model.

ABSTRACT:

Background

Drug-coated balloons (DCBs) are important treatment options for coronary artery disease; however, randomised controlled trials comparing various DCB technologies are sparse, and further investigations are needed.

Aims

This preclinical study aimed to histologically and biologically compare the drug effects and safety of a low-dose paclitaxel-coated DCB (PCB; AGENT), a regular-dose PCB (SeQuent Please NEO) and a sirolimus-coated DCB (SCB; MagicTouch).

Methods

The DCBs were inflated in the healthy iliac arteries of 18 rabbits, which were euthanised after 28 days. The treated iliac arteries and distal skeletal muscles were histopathologically evaluated, and drug concentrations were measured.

Results

In the histopathological evaluation, the medial smooth

SUBMITTER: Aihara K 

PROVIDER: S-EPMC10941670 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature