Nanoparticle mediated photodynamic therapy as a method to ablate oral cavity squamous cell carcinoma in preclinical models.

ABSTRACT: Photodynamic therapy (PDT) is a tissue ablation technique able to selectively target tumour cells by activating the cytotoxicity of photosensitiser dyes with light. PDT is nonsurgical and tissue sparing, two advantages for treatments in anatomically complex disease sites such as the oral cavity. We have previously developed PORPHYSOME (PS) nanoparticles assembled from chlorin photosensitiser-containing building blocks (~94,000 photosensitisers per particle) and capable of potent PDT. In this study, we demonstrate the selective uptake and curative tumour ablation of PS-enabled PDT in three preclinical models of oral cavity squamous cell carcinoma: biologically relevant subcutaneous Cal-33 (cell-line) and MOC22 (syngeneic) mouse models, and an anatomically relevant orthotopic VX-2 rabbit mod

SUBMITTER: Sahovaler A 

PROVIDER: S-EPMC10941731 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature